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July 2017

The 33rd Annual Meeting of ESHRE will be held in Geneva

A representative sample of the team of doctors and biologists of the Reproductive Medicine Service at Dexeus Women's Health attended and actively participated in the 33rd Annual Congress of the European Society of Human Reproduction and Embryology (ESHRE 2017) which was held in Geneva (Switzerland) from 2 to 5 July.

This newsletter provides a brief overview of the presentations given, and scientific posters and papers submitted, and provides information on some of the topics covered in the Committee meetings and work sessions in which Women's Health Dexeus was directly involved.

Does the information given to oocyte recipients influence the decision to transfer one or two embryos?

Does the information given to oocyte recipients influence the decision to transfer one or two embryos?

The donation biology team of the Reproductive Medicine Service of Dexeus Women's Health carried out a study to determine whether the information given to patients on the risks of multiple gestation and the chances of achieving pregnancy with the transfer of a single embryo influences their decision with respect to the number of embryos to be transferred.

Scientific poster: Single or double embryo transfer? Decision-making process in patients participating in an oocyte donation program
Roca M1, Clua E1, Rodríguez I1, Tresánchez M1, Martínez F1, Boada M1, Barri P.N1, Veiga A1
1 Reproductive Medicine Service. Dexeus University Hospital. Barcelona, Spain

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How does response to ovarian stimulation influence the success of assisted reproduction?

How does response to ovarian stimulation influence the success of assisted reproduction?

Ovarian stimulation is a key element in assisted reproduction treatments, but some studies suggest that it may affect oocyte quality or endometrial receptivity. A large multicentre European study conducted by Dr. Nikolaos Polyzos, scientific and clinical director of the Reproductive Medicine Service at Dexeus Women's Health undermines this assumption.

Session 48: Outcomes and ovarian stimulation
Presentation: Cumulative live birth rates following the first ovarian stimulation for IVF/ICSI. A European multicenter analysis of ~15.000 women using individual patient data
Speaker: Polyzos Nikolaos P. Clinical and Scientific Director of the Reproductive Medicine Service, Department of Obstetrics, Gynaecology and Reproductive Medicine, Dexeus University Hospital, Barcelona, Spain

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When the results of an embryo biopsy are inconclusive, is it advisable to repeat the procedure?

When the results of an embryo biopsy are inconclusive, is it advisable to repeat the procedure?

Occasionally, Preimplantation Genetic Screening (PGS) may not yield conclusive results in some of the embryos tested. Scientists are now considering whether it would make sense to thaw the embryos (which is considered safe) and carry out a new biopsy in order to obtain a diagnosis and determine their viability before discarding them.

Communication: Inconclusive PGS results: go for a second biopsy!
Parriego M1, Coll L1, Boada M1, Vidal F2, Mateo S1, Coroleu B1, Veiga A1
1 Department of Obstetrics, Gynaecology and Reproductive Medicine, Dexeus University Hospital, Barcelona, Spain
2 Department of Cell Biology, Physiology and Immunology, Autonomous University of Barcelona, Bellaterra, Spain

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Dr. N. Polyzos, key opinion leader of the ESHRE Guidelines Ovarian Stimulation group

The aim of this ESHRE guidelines project is to provide gynaecologists, medical physicians and embryologists in the field of reproductive medicine, infertility and assisted reproduction evidence-based information on the different options for Ovarian Stimulation in IVF/ICSI.

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Legal issues of concern to assisted reproduction professionals

Legal issues of concern to assisted reproduction professionals

The Association for the Study of Reproductive Biology (ASEBIR) conducted an extensive study of all the legal issues related to assisted reproduction which have been dealt with by its legal consultancy department over the past eleven years. The aim of this study was to establish the mechanisms which contribute to facilitating their resolution. Its findings were presented by Dr. Montse Boada, Head of the Biology Section of the Reproductive Medicine Service at Dexeus University Hospital and current Chairwoman of ASEBIR at the last conference held by the European Society of Human Reproduction and Embryology (ESHRE).

Poster discussion session: What legal aspects worry ART professionals?
Boada M12, Abellán F34
1 Spanish Association for the Study of Reproductive Biology (ASEBIR)
2 Women's Health Dexeus, Barcelona, Spain
3 ASEBIR Legal Consultacy
4 Health Law Consultants, Madrid, Spain

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Is it worth performing a second biopsy in mosaic embryos?

Is it worth performing a second biopsy in mosaic embryos?

Although normal births have been reported after the transfer of mosaic embryos, only limited information is available on the clinical implications of such transfers. The decision to transfer mosaic embryos in assisted reproduction treatments thus remains controversial. A study conducted by Lluc Coll, biologist at the Reproductive Medicine Service at Dexeus Women's Health attempted to find out if performing a second biopsy in mosaic embryos is an effective procedure which can provide additional information regarding their use in assisted reproduction.

Scientific poster: Mosaic embryons: is it worth re-biopsying them?
Coll L1, Parriego M1, Boada M1, Vidal F2, Tresanchez M1, Coroleu B1, Veiga A13
1 Reproductive Medicine Service. Department of Obstetrics, Gynaecology and Reproductive Medicine. Dexeus University Hospital
2 Cell Biology Unit. Autonomous University of Barcelona, Bellaterra
3 Stem Cell Bank. Barcelona Centre for Regenerative Medicine

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Re-evaluating success in ART

Prof Nikolaos Polyzos, Clinical and Scientific Director of the Service of Reproductive Medicine of Dexeus Women's Health, gave a keynote lecture in the MSD symposium entitled “Re-evaluating success in ART: Useful measures in optimizing patient outcomes” along with other key opinion leaders in the field.

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Can preimplantation genetic screening improve outcomes in patients with repeated implantation failure?

Can preimplantation genetic screening improve outcomes in patients with repeated implantation failure?

Embryonic aneuploidy is one of the main causes of repeated implantation failure. However, the indication of preimplantation genetic screening (PGS) in these cases is controversial due to the lack of randomised studies making use of current testing methods. In addition, the study endpoints are implantation and pregnancy rates, when perhaps the focus should be on cumulative live birth rates, even in this indication.

Scientific poster: Cumulative live birth rate after implantation genetic screening in repeated implantation failure: is there still a place for replacing genetically unscreened embryos?
Devesa M1, Coroleu B1, Parriego M1, Coll, L1, Martinez F1, Rodriguez I1, Barri PN1
1 Reproductive Medicine Service. Department of Obstetrics, Gynaecology and Reproductive Medicine. Dexeus University Hospital, Barcelona, Spain

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Can the transfer of a larger semen volume improve insemination outcomes?

Can the transfer of a larger semen volume improve insemination outcomes?

A team of the Reproductive Medicine Service of Dexeus Women's Health, directed by Dr. Jorge Rodríguez-Purata, has carried out a study to determine whether larger than standard donor semen volumes used in intrauterine insemination are able to increase the success rates of such treatment and therefore the live birth rates.

Scientific poster: Inseminated volume 0.2 ml vs. 0.5 ml in donor intrauterine insemination (dIUI) cycles: A randomized controlled trial
Rodriguez-Purata J1, Laura L1, Gonzalez C1, Ballester M1, Rodriguez I1, Martinez F1, Barri PN1, Coroleu B1
1 Reproductive Medicine Service. Dexeus University Hospital. Barcelona, Spain

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Poor responders of ovarian stimulation for IVF:
What are the options?

Can the transfer of a larger semen volume improve insemination outcomes?

In this lecture Prof N. Polyzos provided evidence regarding the management of poor ovarian responders, analyzing the current treatment options for this difficult group of patients. In addition he provided information concerning pioneering treatments for poor responders, several of which are currently under development in the Dexeus Hospital.

Session title: Ovarian stimulation for IVF: Individualisation and beyond...?
Pre-congress course

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