34 symptoms of premenopause: early signs and solutions

Premenopause is the transition stage which marks the beginning of the end of a woman's fertile years. During this time, ovarian function gradually declines and oestrogen and progesterone levels begin to drop.¹

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It usually occurs between the ages of 40 and 50, although its onset and duration can be prolonged by about five years depending on the individual. Factors such as stress, smoking or certain gynaecological procedures can bring forward its onset or shorten its duration.

Although it is a natural process, this stage may involve changes which affect physical and emotional wellbeing.2 At Dexeus Midlife, we support each woman with personalised medical follow-up designed to understand this stage and take care of her holistic wellbeing.

What are the first symptoms of premenopause?

As oestrogen and progesterone hormone levels gradually decrease, the body begins to show the first symptoms of premenopause, a natural process that marks the beginning of a new stage. Below we review the 34 symptoms of premenopause.3

Physical symptoms

  1. Changes in the menstrual cycle
  1. Hot flushes and night sweats
  1. Breast pain or tenderness
  1. Muscle or joint pain
  1. Fatigue or a feeling of exhaustion
  1. Headaches or migraines
  1. Weight gain or loss
  1. Fluid retention or swelling
  1. Mild urinary incontinence
  1. Osteopenia or incipient osteoporosis
  1. Hair loss or weakness
  1. Skin changes
  1. Palpitations or mild arrhythmias
  1. Digestive changes
  1. Changes in cholesterol levels

Emotional and cognitive symptoms

  1. Mood swings and irritability
  1. Anxiety or nervousness
  1. Sadness or low mood
  1. Difficulty concentrating
  1. Forgetfulness or brain fog
  1. Insomnia or waking up at night
  1. Apathy or lack of motivation
  1. Decreased self-esteem
  1. Mental fatigue or lack of energy

Sexual and relationship symptoms

  1. Decreased sexual desire
  1. Vaginal dryness
  1. Pain or discomfort during sexual intercourse
  1. Difficulty maintaining intimacy or connection with your partner
  1. Decreased fertility

Less well-known but common symptoms

  1. Changes in smell or taste
  1. Dizziness and nausea
  1. Fragile or brittle nails
  1. Allergies or increased sensitivity
  1. More intense body odour

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Why do symptoms vary among women?

This transition does not play out the same way for all women: the intensity, frequency and combination of premenopause symptoms depend on each person’s body, lifestyle and stage of life.¹

Some women only notice minor menstrual changes while others experience several symptoms at the same time. That’s why it’s important to have a personalised medical assessment to identify whether the changes are due to premenopause or other causes.

How can the onset of premenopause be identified?

Observing and recording changes in your cycle, sleep or mood can help you spot patterns and recognise the early signs of premenopause

At Dexeus Midlife, we offer an online guidance test which will help you decide whether you might be in this phase or find out more precisely what stage you are at.

What treatments and solutions are available for premenopause?

Premenopause can be addressed from an integrative medical standpoint based on the type of symptoms and the individual needs of each woman.

Hot flushes and night sweats

These symptoms are treated through a personalised hormonal assessment and, when indicated, with hormone replacement therapy. Natural alternatives and lifestyle guidelines are also offered to reduce episodes and improve sleep.

As a complement, the use of topical solutions such as exopeptide balance mist can provide an immediate sensation of freshness and comfort at specific moments. It is a soothing and revitalising facial toner, formulated with bisabolol, lavender extract and hyaluronic acid, which helps to instantly refresh the skin and quickly relieve the feeling of overheating.

Another option is night balance caps, a food supplement formulated with melatonin, ashwagandha, tryptophan and vitamin B6, designed to improve the quality of rest and help reduce insomnia and night sweats.

Finally, day vitality patch is a cooling patch with an immediate rebalancing effect, providing a sensation of comfort and relief from hot flushes.

Insomnia and fatigue


Sleep disturbances and persistent fatigue are addressed through personalised assessment and bespoke treatments, which may include hormonal adjustments, sleep recommendations and support from natural therapies.

Vaginal dryness and pain during intercourse


We offer regenerative gynaecology treatments such as vulvovaginal hydration with hyaluronic acid fillers, vaginal laser, platelet-rich plasma (PRP) or regenerative mesotherapy, which help restore elasticity and natural lubrication, along with pelvic floor physiotherapy when necessary.

Decreased libido


Decreased sexual desire is addressed holistically, combining hormonal, emotional and relational assessment. Intimate regenerative therapies coupled with natural therapies or hormone treatments can enhance intimate wellbeing and sexual satisfaction.

Weight gain and bloating


During this stage, metabolic changes may occur which alter the distribution of body fat. At Dexeus Midlife, we offer comprehensive assessment which combines gynaecology, nutrition and behavioural therapy, plus hormone or natural treatments based on individual needs.

Joint pain


Treatment includes medical assessment, adapted physical activity and in some cases physiotherapy or hormone treatment. The goal is to improve mobility and reduce inflammation.

Mood swings and memory loss


They are addressed with a combined cognitive, hormonal and emotional health approach. Psychological support, emotional education and hormonal adjustments can improve stability and mental clarity.

Loss of skin firmness and elasticity

The hormonal changes typical of this stage can accelerate the appearance of signs such as sagging, loss of density, dryness or a lack of radiance in the skin.

exopeptide cream provides nourishment and helps to redensify the skin. exopeptide serum, in turn, works intensively on skin elasticity and skin quality.

Developed by mesoestetic®, both have been specifically formulated to respond to the skin’s needs during this stage. Their combined use helps to reinforce the skin barrier, restore density and achieve revitalised skin. They are a complementary skincare routine that supports the changes associated with menopause.

Hair


Changes in hair associated with hormonal variations can be addressed with hormone treatments, natural therapies and aesthetic and regenerative techniques, such as mesotherapy and microneedling.

Holistic wellbeing


The symptoms of premenopause are part of a global process. Each case is thus addressed from a holistic perspective, seeking to strike a balance between hormonal, physical and emotional health.

To take care of your wellbeing in this new stage, you can ask for an appointment at the Dexeus Midlife centre. Our team, which specialises in all stages of menopause, delivers friendly, personalised care using safe and effective treatments.


References

¹ Dexeus Midlife – Premenopause, https://www.dexeus.com/midlife/salud-ginecologica/premenopausia/

2 MedlinePlus – Menopause, https://medlineplus.gov/spanish/menopause.html


3 https://medlineplus.gov/spanish/menopause.html

Oriol Gil
Oriol Gili
Chemist with expertise in dermopharmacy

A chemist specialised in dermopharmacy and women’s health with more than 5 years of experience in pharmaceutical advice applied to skin care.

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